finally, phenmetrazine analogues are hitting market
I've read about it before and it piqued my interest. I fucking love a good stimulant, hopefully my brain hasn't become so fucked up that they don't function properly anymore. Some people legitimately do not react (as they should). Wonder how this would combine with an MAOI. Dexamph is used in low doses, up to 30mg even, although of course you have to be very careful and start off low. Wiki says there'n no significant effect on serotonin, which is the main thing you need to worry about. The less effect on norepinephrine the better, unless you need a safe boost. MAOIs actually tend to decrease norepinephrine eventually and cause hypotension, which stimulants can help alleviate.
I'd love to experiment with a low dose 2-FMA + Parnate combo. Serotonin is a concern. Reading about desoxyn (meth) used with MAOIs right now. Of course I'd have the necessary medications to treat an adverse reaction on hand. This is making me consider whether Nardil + a stimulant would have been an even better choice. I'll wait 3 months max while increasing the dose at intervals, then order Nardil powder from my vendor if it doesn't work out.
The lack of serotonin is the problem. Need to have some SRI to make a good recreational stim (see: cocaine, cocaethylene).
3-fluorinating it like they did here will have some effect on that but hardly, if we are to go off the two closest relatives, 3-fluoromethcathinone and 3-fluoroamphetamine, both of which negligibly affect serotonin. Obviously, they were trying to craft an analogue to be the closest to plain phenmetrazine as possible, but I'm actually worried it will backfire. 3-subs on the benzene aren't good historically for the heart. Recreationally speaking, 3-FA seems to be more selective for dopamine, 3-FMC the same way. In the end I'm pretty sure they both turned out to be, more or less, straight stims by themselves.
4-ethylphenmetrazine is probably a winner. Increased lipophilicity to better cross the BBB, increased potency, increased affinity for serotonin (based off 4-ethylmethcathinone - don't seem to have any data for 4-ethylamphetamine). 4-methyl by virtue is probably good too. Dopamine reuptake inhibitors don't seem to take much issue with steric hindrance, in fact, if you look at them, they tend to be pretty big bulky molecules.
I'd next check 4-fluoro - & I'm kind of surprised that's not what was started with... But we won't know for sure until bioassays of 3F-phenmetrazine start to pop up to tell us, can we treat the phenmetrazine skeleton like a rigidified cathinone (ethcathinone), or more like an amphetamine, or neither.
Also, binding affinity data is not the be all end all of a drug's potential. You should know that, c'mon... there are many drugs that look great on paper but turned out to be shit. Ethylphenidate off the top of my head. To that end... phenmetrazine may look good, but if that morpholine ring splits in vivo, suddenly you have a big floppy b-ethoxy which if its anything like b-MeO will love itself some norepinephrine. Similar to the cathinones which so readily metabolized to nasty ass ephedrine metabolites.
So in the end you don't know until you try... spray and pray all you like, sometimes you hit sometimes you miss.
I'll be picking some up when I order my end-of-year supplies this coming week (provided bonuses get paid out) so I'll report back.
