Evaluate what you use the computer for and figure out whether you really need to be running Windows. If not, get into Linux and avoid most consumer-grade malware by way of incompatibility.
Otherwise, get Comodo Internet Security. Don't worry about the actual AV engine or firewall or any of that. Just use the bit that manages what processes are allowed to run. Start with a total blacklist and whitelist processes (their specific actions rather) as they try to run until all your usual stuff is allowed. Unknown processes attempting to run as well as files written in a driveby download will be caught. Don't approve blindly. Google the unknowns and you'll be golden.