Author Topic: The retarded thread: Send zok back to africa edition  (Read 107720 times)

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Offline John Smith

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Re: The retarded thread: Send zok back to africa edition
« Reply #1620 on: October 30, 2014, 09:11:44 am »
Sploo, have you ever tried weight lifting? The increase in cognition afterward is very noticeable. You get massive increases in blood pressure and blood flow to the brain, particularly with a belt during heavy deadlifts and squats.

What do you think about BPAP? A nootropics vendor may carry it soon: http://www.reddit.com/r/Nootropics/comments/2kp0cb/can_ceretropic_stock_bpap/

http://en.wikipedia.org/wiki/Benzofuranylpropylaminopentane
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BPAP (along with another similar compound PPAP) is classified as a catecholaminergic and serotonergic activity enhancer. This means that it stimulates the impulse propagation mediated transmitter release of the neurotransmitters dopamine, norepinephrine and serotonin in the brain. However, unlike stimulant drugs like amphetamine, which release a flood of these neurotransmitters in an uncontrolled manner, BPAP instead only increases the amount of neurotransmitter that gets released when a neuron is stimulated by receiving an impulse from a neighbouring neuron. So while both amphetamine and BPAP increase the amount of neurotransmitters that get released, amphetamine causes neurons to dump neurotransmitter stores into the synapse regardless of external input, while with BPAP the pattern of neurotransmitter release is not changed, but when the neuron would normally release neurotransmitter, a larger amount than normal is released.

It really does sound magnificent, doesn't it? First became aware of it a while and had it in a text file.
Some relevant discussions, if you're interested:
http://www.bluelight.org/vb/threads/703868-BPAP-Monoamine-activity-enhancer
http://www.longecity.org/forum/topic/68076-bpap-discussion-experience-feedback/
http://www.longecity.org/forum/topic/7539-bpap/
http://www.longecity.org/forum/topic/63823-bpap-group-buy/

Got a half ounce of weed, bottle of Woodford Reserve, 6 pack of Flying Dog Gonzo Imperial Porter 9.2% and a 12 pack of Great Lakes Brewery variety to hold me over at this Halloween party I'm going to

My retard friend was like "alcohol technically wakes you up because it breaks down into sugar"

Well, well, look who's become the social butterfly.  :suspect:

Offline splooge gook

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Re: The retarded thread: Send zok back to africa edition
« Reply #1621 on: October 30, 2014, 12:57:19 pm »
Sploo, have you ever tried weight lifting? The increase in cognition afterward is very noticeable. You get massive increases in blood pressure and blood flow to the brain, particularly with a belt during heavy deadlifts and squats.

yes, that is why people warm up before doing things
Everything I post iz fiction

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Offline splooge gook

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Re: The retarded thread: Send zok back to africa edition
« Reply #1622 on: October 30, 2014, 01:03:51 pm »
so it sounds similar to my idea on an antianxiety XR pill that would only dissolve in response to stress hormones. it sounds like it amplifies you rather than shifts you. that's just a guess from it being dependent on the nerve impulses, but really i have no idea and i want to remind you that just because an antidepressant has a mechanism of action that is novel or looks promising means very little. it's what actually observably happens, we can't extrapolate on theory based on theory, it might be bunk as anything else. serotonin receptor inhibition is a massive thing but how many people notice/care/are affected by it? if it does work it may only work for a select few. the "holy grail" of antidepressant drugs seems far to come if it isn't Esketamine, a lot more info on neurogenesis is found soon, and i'm curious why any time 5HT1A receptor full agonists (5HT1A receptor partial antagonists are a type of anxiolytic/antidepressant like buspar) went through clinical trials, they were not only dropped, but never dropped for any disclosed purpose. seems fishy tome
Everything I post iz fiction

"I've shot meth before, is it water soluble?" -semiazas
"I fapped so much and talked to Semiazas. I was addicted from that point forward." - DARE

https://www.zoklet.net/bbs/showthread.php?t=276946 (use internet wayback)

Offline splooge gook

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Re: The retarded thread: Send zok back to africa edition
« Reply #1623 on: October 30, 2014, 01:07:54 pm »
The last time you asked I said it depended on what you had in mind. You never responded.

If you haven't already figured it out, focus on the HBD (human biodiversity) community, that's where the good info comes up. It's the non-superficial differences that really matter, and that's what most of the focus is on. You can find very interesting information if you do digging, because you're harvesting the fruits of people who have done much digging themselves in places where few look, on very taboo subjects. People who are genuinely very intelligent and knowledgeable. Read "The 10,000 Year Explosion".

I'm currently dealing with the recurrent desire to completely give up on life and worrying about possibly developing some form of schizophrenia. Damned if you don't, less damned if you do. Humans weren't meant to be alone and driving yourself to the level of alienation and isolation that I have is one of the worst things you could realistic do to yourself. I genuinely don't want to have relationships, I want to be able to be happy alone, but I also acknowledge  biological reality and limitations. Having a natural makeup that makes you horribly suited for social interaction and relationships, a genuine natural hatred and repulsion towards humanity, easy to maintain isolation for periods of time that then make it very difficult to reintegrate, yet still suffering the effects of it. It's akin to being allergic to water, I've thought. Could you really connect with others if you viewed them essentially as a nutritional supplement? Interchangeable and illusory?

What I had in mind was mostly aptitude/IQ type questions, perhaps some other instruments come up as i think of them. This can easily be applied to your own interests of human biodiversity. once a decent sample size can be aquired, results can be analyzed by facctors such as race, as well as the interactions between race, other demographic data, and discrepancies on different subtests of ability in certain populations. this could help confirm theories that those of certain ethnicities are more likely on average to have deficits/gifts in one type of cognitive ability vs the other and etcs
Everything I post iz fiction

"I've shot meth before, is it water soluble?" -semiazas
"I fapped so much and talked to Semiazas. I was addicted from that point forward." - DARE

https://www.zoklet.net/bbs/showthread.php?t=276946 (use internet wayback)

Offline Piles of Crack

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Re: The retarded thread: Send zok back to africa edition
« Reply #1624 on: October 30, 2014, 07:07:28 pm »
Send me some Parnate Malice

Offline Max Headroom

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Re: The retarded thread: Send zok back to africa edition
« Reply #1625 on: October 30, 2014, 07:38:07 pm »
#&
Noo rick sims
noo jello biafra
noo
This is Max Headroom. I'M SPECIAL. I'M UNIQUE. I'M DIFFERENTIAL.
THAT'S BECAUSE YOU'RE AIR CONDITIONED TO THE USUAL.
THIS IS ME, MAX HEADLAMP. AND IF YOU DON'T LIKE IT, YOU CAN STICKSHIFT IT IN YOUR EXHAUST PIPE AND CHOKE IT.
ASS SMOKE IT.


Offline bling bling

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Re: The retarded thread: Send zok back to africa edition
« Reply #1626 on: October 30, 2014, 07:40:26 pm »
ah shit

Offline Zero

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Re: The retarded thread: Send zok back to africa edition
« Reply #1627 on: October 30, 2014, 11:43:57 pm »
Watching Dexter smoking major cheese.
"Those who will not reason, are bigots, those who cannot, are fools, and those who dare not, are slaves."

Lord Byron

Offline John Smith

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Re: The retarded thread: Send zok back to africa edition
« Reply #1628 on: October 31, 2014, 12:35:46 am »
What I had in mind was mostly aptitude/IQ type questions, perhaps some other instruments come up as i think of them.

What for? The field of psychometrics is already pretty well developed. There's no way you're going to produce anything significantly better than what's already available, the correlations with g are just too high, or novel. Raven's progressive matrices is already the best standard, unless you want to measure "verbal intelligence". You've said before "psychometrics is hardly a real science", and hopefully you didn't assume that just off a few wikipedia articles.

If you really want to get into the meat of it, the fundamentals, this is pretty much the bible: http://www.amazon.com/The-Factor-Evolution-Behavior-Intelligence/dp/0275961036

Long and dry, has statistical analysis. Good luck getting through it, I didn't, but I may pick it up again one day.

Send me some Parnate Malice

http://webcache.googleusercontent.com/search?q=cache:JnFUfQig8ooJ:zoklet.net/bbs/archive/index.php/t-304792-p-26.html+&cd=2&hl=en&ct=clnk&gl=us
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Piles of Crack
07-15-2014, 11:24 AM
Open a vein Malice

:suspect:

If you want I could PM you the email of my source. Try to haggle as hard as you can, I want to see what the lowest they'd be willing to go is, and ask for CoAs for both tranylcypromine and phenelzine (don't use the trade names). Let me see the CoAs if he gives them to you and the lowest price you can get so I can see if everything still checks out.

If social anxiety/difficulty is your main problem, try Nardil. Healthy social relationships, intimacy, are by far the biggest factor for you and me, and this will make things much easier. Let's not fool ourselves. IIRC there's been at least one study that showed it's even more effective than Xanax, and you'll have the effect constantly without tolerance or withdrawals!

If you need a stimulant boost, you can augment it with very low doses (starting around 1mg, but some people can go up to 30) of Dexedrine or the equivalent from Vyvanse. Other stims may work as long as the effect on serotonin is around equal to or lower. I'd like to see how 2-fma interacts with it, but serotonin syndrome is pretty serious, although you can easily buy what you'd need in case of an emergency and carry it in a wallet, same for a hypertensive crisis: http://www.drsfostersmith.com/product/prod_display.cfm?pcatid=9702

Parnate may be overall better on it's own, except for anxiety. You could possibly augment it with tian ma/gastrodia elata (extract) (gaba-t inhibitor) or gotu kola, which may activate the enzyme that produces GABA from glutamate. Glutamate levels may be elevated in those with depression and other disorders. A search of the NCBI produced some interesting lengthy papers on glutamatergic hypotheses.

And as I've said before, the risks are ridiculously overblown. You're already willing to try, but if you ever have some doubts, think of this: You told me before you weren't willing to because there were too many interactions, but were both largely using drugs to self-medicate, which we wouldn't need if we were healthy. Drugs don't even make me feel good anymore, they just make things bearable, or mildly pleasant, which is the best you can often hope for relative to how you normally feel. Would you rather feel good all the time or momentarily and deal with all the negatives of drugs, the withdrawal/rebound, health effects, unsustainability etc.? We both know there's no way this is going to work out, I've accepted it, and that standard mild antidepressants aren't going to cut it. Even esketamine doesn't have that strong an effect on depression rating scales.

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The reduction was statistically significant, and shows an important role for glutamate in anhedonia, however clinically going from a score on SHAPS from 36 to 30 is still... well... clinically significantly anhedonic.

For comparison, in this group, after 14 days the Ketamine group had a reduction in MADRS score from averaging about 38 to about 34. Compare this to (Guelfi, J. D., N. Strub, and H. Loft. "Efficacy of intravenous citalopram compared with oral citalopram for severe depression: safety and efficacy data from a double-blind, double-dummy trial." Journal of affective disorders 58.3 (2000): 201-209.) IV or tablet citalopram reduces MADRS scores from about 38 to about 17. This is a bit of apples-to-oranges, as the ketamine study was looking at bipolar patients with treatment resistant depression, and the citalopram study was not. But I am using this to show what a RESPONSE in depression looks like

Offline Lanny

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Re: The retarded thread: Send zok back to africa edition
« Reply #1629 on: October 31, 2014, 02:01:19 am »
Hey malice, do you know anything about modafinil/provigil? I know some high power career types that are all over that shit, but apparently they don't sleep anymore or something. From what I'm reading it sounds pretty cool but it's like one of those too-good things and I'm afraid gonna have a delayed effect and fry my brain or some shit in 10 years.

Offline John Smith

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Re: The retarded thread: Send zok back to africa edition
« Reply #1630 on: October 31, 2014, 02:55:09 am »
Really? That's such old news.

http://www.gwern.net/Modafinil

Examine is a very good source of information, remember it: http://examine.com/supplements/Modafinil/

I can't use it, at least right now, because it triggers depressive episodes for me, along with piracetam. I think it's most likely because of the pro-glutamatergic effects it has, but my brain is abnormal so my experiences probably won't be applicable to others. I ordered a 30/30 pack of 150mg armodafinil and 200mg modafinil and still have 27-1/2 and 19-1/2 pills I probably won't use.

My opinion: It's weak sauce. The only real benefit is the lack of drug interactions, negative health effects, withdrawal and addiction. The people who think it has amazing effects are likely people that have never used stimulants/are pussies afraid of hard drugs, are experiencing a strong placebo effect, or are rare super-responders. If you want something noticeable, buy 2-fma. But if you're worried about modafinil you're probably too much of a wuss for a methamphetamine analog: http://www.reddit.com/r/RCSources/

On the above, remember that the dose makes the poison and there are a wide variety of other things to consider, such as impurities, lifestyle factors, confounding variables etc. Low doses actually appear to be beneficial, and pharmaceutical meth can actually be prescribed for ADD under the name Desoxyn and is often reported as being "smoother" than Adderall (mixed amphetamine salts).
http://www.ncbi.nlm.nih.gov/pubmed/21635908
The doses used weren't even that low: 0.1mg, 0.5mg, and 1mg /kg/hr
http://www.ncbi.nlm.nih.gov/pubmed/24333768

Really, it's so weak I'd compare it to caffeine combined with l-theanine. It's not even worth using unless you're cycling it with other things to prevent tolerance, or can't use something else due to drug interactions or drug testing.

Offline Piles of Crack

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Re: The retarded thread: Send zok back to africa edition
« Reply #1631 on: October 31, 2014, 03:05:29 am »
Attempting to roll a 7 gram blunt

Offline Lanny

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Re: The retarded thread: Send zok back to africa edition
« Reply #1632 on: October 31, 2014, 03:24:58 am »
Really? That's such old news.

Yeah, I'm behind the times, sue me.

Quote
My opinion: It's weak sauce. The only real benefit is the lack of drug interactions, negative health effects, withdrawal and addiction. The people who think it has amazing effects are likely people that have never used stimulants/are pussies afraid of hard drugs, are experiencing a strong placebo effect, or are rare super-responders. If you want something noticeable, buy 2-fma. But if you're worried about modafinil you're probably too much of a wuss for a methamphetamine analog: http://www.reddit.com/r/RCSources/

Nah, I've done stimulants recreationally, it was actually the non addictiveness and lack of negative effects that psyched me out. But yeah, I'd buy that people who rave over it are blowing it out of proportion. I'm kinda shopping around for a, uhh, I don't want to say cognitive enhancer but like a get shit done drug. Probably was the dosage but my experiences with meth were definitely not that. Adderall's not bad but I'm a noob with no good online sources and trying to drum some up on a campus is a total crapshoot.

Offline BallsDeep69

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Re: The retarded thread: Send zok back to africa edition
« Reply #1633 on: October 31, 2014, 06:57:45 am »
Just found out: Zok has actually moved to Africa and caught Ebola. He died two days later. *fanfare plays*
My will, as it were.
To Zek, get over the fucking kittens man.

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To Arnox, fuck you.

Offline Gollumkip

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Re: The retarded thread: Send zok back to africa edition
« Reply #1634 on: October 31, 2014, 07:07:16 am »
Y'all niggas toasting in a roll bread.
8=====D