-Comprehensive- Been on psychotropic drugs? Did they subjectively change you?

[splooge gook]

Well I'm going to start out by saying I started an anti-seizure drug that is used off label for BiPI, BiPII, whatever else there is. oxcarbazepine. I've been feeling pretty slow and shitty for the past few days but I can't tell if that's from overlapping drug hangovers or the part of me that felt normal and better for a while has been dulled by anti-mania.

i can tell what my different experiences with all psych meds have been.

zoloft 25-150mgs: did nothing, felt a bit unpleasant for a few days. When I ate a few grams of the stuff I soft of tripped out on it.

effexor 150mgs: nothing

strattera: stomach pains; nothing

remeron: the only antidepressant that ever helped me. when i was on 30mgs i gained 40 pounds over 3 months, which went back down after discontinuation/speed. being on 15mg immediately took me out of a bad place. stopped it because i actually feel like it helped "cure" it in a way

doxepin 50mg: the "if you really need to fall asleep quickly you can take this but you're gonna regret it in the morning" pill

180mg of cymbalta: got bored on my birthday and ate all of my aunt's prescription medication. was extremely manic for about 4 hours. as in,jumping off walls rulnning around the house playing tag with 4 year olds manic.

xanax: when i first got put on xanax at 14 i just abused the shit out of them, but my anxiety did go away. now that i'm on 2mg XR once in the day, i rarely take more than prescribed, and most of negative emotions have been dulled.

klonopin: Didn't do much. also, i don't remember.

adderall/vyvanse 5-30, and 30mgs: kept me focused for a while on 30mgs but i was basically just taking it to be euphoric during school because it was so boring. i'd crash every day after like 5-6 and write multipaged IWD-style meth rants to my "ex" about how much i want to die.





i became increasingly more psychotic, when i went down to 15mgs, and then 5mgs, thespeed tics and teeth grinding mostly went away. the 30mg vyvyanse, is like a smoother, longer lasting 10mg adderall, whic is what i'm on now

depakote: read about liver side effects, never took

seroquel: helped me sleep through school, made me super autistic and aloof for a year or two

trazadone: 6/10 sleeping pill. not too much of a hangober/ nevertook as an AD

[splooge gook]

bump

[millionsofdeadcats]

You need a hysterectomy

[Zanick]

I used to be on Lexapro and Adderall. I spent most of my time reading about serial killers with worrisome enthusiasm, and when I wasn't doing that I'd be masturbating. It usually took an hour to finish.

[splooge gook]

I used to be on Lexapro and Adderall. I spent most of my time reading about serial killers with worrisome enthusiasm, and when I wasn't doing that I'd be masturbating. It usually took an hour to finish.

is that from the lexapro or adderall? was the violence sexually themed? different ADs would make my fantasies weirder than they usually were

i wonder what's up with SSRIs that seems to cause violence and depravity in people. i guess the emotions of guilt and whatever else are numbed out from the serotonin

[Zanick]

I used to be on Lexapro and Adderall. I spent most of my time reading about serial killers with worrisome enthusiasm, and when I wasn't doing that I'd be masturbating. It usually took an hour to finish.

is that from the lexapro or adderall? was the violence sexually themed? different ADs would make my fantasies weirder than they usually were

i wonder what's up with SSRIs that seems to cause violence and depravity in people. i guess the emotions of guilt and whatever else are numbed out from the serotonin

It was a long time ago, but I don't think there was violence incorporated into my sexual thoughts. Those were always two separate worlds. Otherwise, I felt like a calculating sociopath most of the time. It freaked out a lot of people close to me.

[mashleshmash]

What a shitty list of drugs, sploo.

[John Smith]

Sploo, try this, you can skip the NSI if you want: http://www.zoklet.net/bbs/showpost.php?p=4780384&postcount=8959

[Rizzo in a box]

seroquel: helped me sleep through school, made me super autistic and aloof for a year or two

trazadone: 6/10 sleeping pill. not too much of a hangober/ nevertook as an AD

http://www.madinamerica.com/2012/09/more-evidence-that-antipsychotics-shrink-the-brain/
http://www.psychiatrictimes.com/articles/antipsychotics-and-shrinking-brain
http://www.nature.com/news/2011/110207/full/news.2011.75.html
http://www.ncbi.nlm.nih.gov/pubmed/21300943

The investigators found that gray matter volumes of all brain regions except for the cerebellum decreased over time; white matter volume on average was unchanged. Subjects who had received higher average lifetime doses of an antipsychotic had less gray matter at baseline and at all future time points. Neither antipsychotic dose nor type of antipsychotic (first-generation, second-generation, or clozapine) appeared to influence the rate at which gray matter loss progressed over time. In contrast, patients who received a low-dose antipsychotic tended to have modest increases in white matter volume over time compared with modest white matter loss in patients whose lifetime average dose was higher. The only advantage for second-generation antipsychotics over typical antipsychotics was a reduction in parietal white matter loss over time.

Background
The association between the course of cognition and long-term antipsychotic medication in schizophrenia remains unclear. We analysed the association between cumulative lifetime antipsychotic medication dose and change of verbal learning and memory during a 9-year follow-up.

Method
Forty schizophrenia subjects and 73 controls from the Northern Finland Birth Cohort 1966 were assessed by California Verbal Learning Test (CVLT) at the ages of 34 and 43 years. Data on the lifetime antipsychotic doses in chlorpromazine equivalents were collected. The association between antipsychotic dose-years and baseline performance and change in CVLT was analysed, controlling for baseline performance, gender, age of onset and severity of illness.

Results
Higher antipsychotic dose-years by baseline were significantly associated with poorer baseline performance in several dimensions of verbal learning and memory, and with a larger decrease in short-delay free recall during the follow-up (p = 0.031). Higher antipsychotic dose-years during the follow-up were associated with a larger decrease of immediate free recall of trials 1–5 during the follow-up (p = 0.039). Compared to controls, decline was greater in some CVLT variables among those using high-doses, but not among those using low-doses.

Conclusion
This is the first report of an association between cumulative lifetime antipsychotic use and change in cognition in a long-term naturalistic follow-up. The use of high doses of antipsychotics may be associated with a decrease in verbal learning and memory in schizophrenia years after illness onset. The results do not support the view that antipsychotics in general prevent cognitive decline or promote cognitive recovery in schizophrenia.

http://www.schres-journal.com/article/S0920-9964%2814%2900327-2/abstract

Continuing brain volume reduction occurs in schizophrenia in early middle-age. However, there is considerable inter-individual variability in the rate of brain volume reduction. At present, the clinical significance of brain volume reduction is uncertain and further research on this topic is of critical importance [45]. Antipsychotic medications may contribute to progressive brain volume reduction in schizophrenia, in accordance with previous predictions based on clinical and preclinical research [8], [35], [36], [40].

http://www.plosone.org/article/info:doi/10.1371/journal.pone.0101689

Need I continue? I think you get the picture.

[John Smith]

Sploo, this would be absolutely perfect for you to experiment with, it's incredibly easy, safe, and you just need melatonin:

http://www.shroomery.org/forums/showflat.php/Number/8557829/fpart/all/vc/1

I made an account on here because I just had to post, sorry if no one cares any more because it's been over a year since the last post in this thread.

Freebasing melatonin will get you fucked up. Super fucked up.

It all started when I ordered some Melatonin pills off the Internet because I liked the feeling of the GNC's 5Mg melatonin, but I hated taking so many pills. I got a 20Mg Melatonin per pill bottle and me and some friends would take them to enhance our smoking. Well one day my friend was looking really hard at a pill and noticed it was filled with powder, so we broke it open... and behold, pure melatonin powder with none of the pill casing.

My friend(s) snorted it but I didn't think it was safe so I stepped down. Later that night one guy had the idea of taking some foil, putting it in to a V shape, burning the underside with a lighter and sucking up the fumes with a straw, AKA freebasing. This sounded even less healthy that snorting it (and all my friends later said that the snorting did very little) but when I started seeing people go from completely fine to completely fucked out of there mind after freebasing, I had to give it a go.

One moment I'm sucking in to a straw and the next I'm trying to figure out where the fuck I was. It was a mixture between being drunk and tripping without visuals, because my mind was in another world completely. My mind keep bouncing between thinking about too much and thinking about too little.

I have no idea if this is safe, and I don't want to do it again until I can get some evidence on it being okay, but I think everyone with access to melatonin powder needs to try it out at least once, it's a whole different experience.

Hey everyone, so i have been quite interested in melatonin for awhile and i came upon this thread. I dissolved 15 5mg tablets in warm water then poured it through a coffee filter. I tried evaporating the water with a fan blowing over it for a few hours and it the water was just not leaving. So i put the solution in a glass dish and put that on a very low heat on the stove. I also added some rosemary because i'm not too fond of smoking freebase. After 30 minutes or so all that was left was a yellowish goo which clumped to the rosemary. I let the dish cool and i scraped it all out with a razor blade.
Around bed time i decided to try this stuff out, so i put some of the rosemary in my bowl along with some goo. I smoked it as if i would DMT (not letting the flame touch the stuff) and what i felt was way way more than a placebo. I realize that rosemary is slightly psychoactive but, i have tried smoking rosemary alone and it was not nearly as powerful as what i felt. I felt almost drunk with a very pleasant body high. It's hard to describe what it felt like but, i had a sense of euphoric sleepiness. My legs were quite wiggly but i never lost balance.
I had recently been having trouble sleeping even when i take some melatonin before bed but i fell asleep very quickly that night. The next day i felt so energized and i had a constant natural high through out the whole day.
I don't plan to do this often because the smoke was very harsh and my throat hurt afterwards, and also i don't want to disrupt my normal sleeping patterns with too much melatonin.
I hope this was helpful!

[Rizzo in a box]

Melatonin isn't going to get you high. http://isomerdesign.com/PiHKAL/read.php?id=35&domain=tk

freebasing it is a retarded idea to boot

[splooge gook]

seroquel: helped me sleep through school, made me super autistic and aloof for a year or two

trazadone: 6/10 sleeping pill. not too much of a hangober/ nevertook as an AD

http://www.madinamerica.com/2012/09/more-evidence-that-antipsychotics-shrink-the-brain/
http://www.psychiatrictimes.com/articles/antipsychotics-and-shrinking-brain
http://www.nature.com/news/2011/110207/full/news.2011.75.html
http://www.ncbi.nlm.nih.gov/pubmed/21300943

The investigators found that gray matter volumes of all brain regions except for the cerebellum decreased over time; white matter volume on average was unchanged. Subjects who had received higher average lifetime doses of an antipsychotic had less gray matter at baseline and at all future time points. Neither antipsychotic dose nor type of antipsychotic (first-generation, second-generation, or clozapine) appeared to influence the rate at which gray matter loss progressed over time. In contrast, patients who received a low-dose antipsychotic tended to have modest increases in white matter volume over time compared with modest white matter loss in patients whose lifetime average dose was higher. The only advantage for second-generation antipsychotics over typical antipsychotics was a reduction in parietal white matter loss over time.

Background
The association between the course of cognition and long-term antipsychotic medication in schizophrenia remains unclear. We analysed the association between cumulative lifetime antipsychotic medication dose and change of verbal learning and memory during a 9-year follow-up.

Method
Forty schizophrenia subjects and 73 controls from the Northern Finland Birth Cohort 1966 were assessed by California Verbal Learning Test (CVLT) at the ages of 34 and 43 years. Data on the lifetime antipsychotic doses in chlorpromazine equivalents were collected. The association between antipsychotic dose-years and baseline performance and change in CVLT was analysed, controlling for baseline performance, gender, age of onset and severity of illness.

Results
Higher antipsychotic dose-years by baseline were significantly associated with poorer baseline performance in several dimensions of verbal learning and memory, and with a larger decrease in short-delay free recall during the follow-up (p = 0.031). Higher antipsychotic dose-years during the follow-up were associated with a larger decrease of immediate free recall of trials 1–5 during the follow-up (p = 0.039). Compared to controls, decline was greater in some CVLT variables among those using high-doses, but not among those using low-doses.

Conclusion
This is the first report of an association between cumulative lifetime antipsychotic use and change in cognition in a long-term naturalistic follow-up. The use of high doses of antipsychotics may be associated with a decrease in verbal learning and memory in schizophrenia years after illness onset. The results do not support the view that antipsychotics in general prevent cognitive decline or promote cognitive recovery in schizophrenia.

http://www.schres-journal.com/article/S0920-9964%2814%2900327-2/abstract

Continuing brain volume reduction occurs in schizophrenia in early middle-age. However, there is considerable inter-individual variability in the rate of brain volume reduction. At present, the clinical significance of brain volume reduction is uncertain and further research on this topic is of critical importance [45]. Antipsychotic medications may contribute to progressive brain volume reduction in schizophrenia, in accordance with previous predictions based on clinical and preclinical research [8], [35], [36], [40].

http://www.plosone.org/article/info:doi/10.1371/journal.pone.0101689

Need I continue? I think you get the picture.

i was aware of this after doing some researching, but i was only taking 25-50mg a night to sleep. at one point theyput me on 200mg of seroquel for sleep (out of all the sleeping medications, 200mg of seroquel? is that legal?), after a few months of that i pretty much slept 14 hours a day, had no personality or social skills, and wanted to kill myself often enough. a few months later off the medication those problems mostly went away. i didn't feel like reading through ten different sources but is the damage generally reversible over time after cessation of the drug?

pretty ironic that the anti-drugs are main ones that cause widespread neuronal cell death