dopamine levels after propylhexedrine (benzedrex)

[dopeman420]

I love stims ADD meds and especially benzedrex. Benzedrex gives me a fucking awesome 6 hours of focus which consist of 3 hours of extreme motivation and such clarity and ease of thought that it's absolutely fucking incredible what I can accomplish and 3 hours of above baseline focus. It's been 2 weeks since the last time I did benzedrex but I still feel dumb, dumber than before I did it. Can benzedrex really make me feel dumb (lowered focus, control of emotions, etc that indicates low level of dopamine) for that long? Also how do I get prescribed adderall?

[Eli]

1.Evaluation by a psychiatrist.
2.Get meds.
3.Profit.

[dopeman420]

1.Evaluation by a psychiatrist.
2.Get meds.
3.Profit.

the strength of street knowledge has been witnessed

[Daran]

There's probably some other confounding factors at play here. I've combined amp and propylhexedrine together even and didn't feel any sort of residual cognitive deficit although the drug itself feels "dirty" to me if that means anything.

[dopeman420]

There's probably some other confounding factors at play here. I've combined amp and propylhexedrine together even and didn't feel any sort of residual cognitive deficit although the drug itself feels "dirty" to me if that means anything.

i have been thinking that i am bipolar and that doing uppers causes me to go into a hypomania (the next few days i feel fucking great after the drug's worn off) that then goes into a depression which makes me stupid

[AlHarringtonCHN]

There's probably some other confounding factors at play here. I've combined amp and propylhexedrine together even and didn't feel any sort of residual cognitive deficit although the drug itself feels "dirty" to me if that means anything.

i have been thinking that i am bipolar and that doing uppers causes me to go into a hypomania (the next few days i feel fucking great after the drug's worn off) that then goes into a depression which makes me stupid

Most typical Amphetamines have a fairly long half-life, so you are experiencing normal results of light-moderate to moderate usage. Afterglow/normal for 2-3 days then below baseline Dopamine along with Serotonin & NE levels. Below baseline Dopamine/NE decreases Cognative abilities.  The lower it gets the more depressed you get and cloudier your head gets.

A real rough estimate is multiply the half-life by 6 to get the "afterglow" and/or "normal" and/or "withdrawal" delay. Thus we typically begin most Opiate withdrawal roughly about 24 hours because typical used Opiates have 4-6 hour half-lives. Methamphetamine has an approx 9-12 hour HL so we get 2.5-3 days roughly. Now look at Cocaine's HL of under an hour and it becomes more apparent why the crash and "fiending" can be so intense within a few hours.

Comedown and physical/mental "withdrawl" are a function of many factors such as: length of time on substance, dosage schedual, rate at which you increase dosage to adjust for tolerance, sleep schedual,  roi, nutrition, and so on... the first four are major determinants especially for the Amphetamine class. The more you "shock" your Neurotransmitters the worse the depression. More you tweek and don't sleep the more intense the exhaustion. Cause and effect.

So a light user who keeps a decent sleep schedual will usually "feel" an afterglow for 2-3 days and function fine, then experience a week or so of Fatigue and mild depression. A light-moderate to moderate user may feel a mild afterglow
With some degree of fatigue for the 3 or so days after then likely significant fatigue with stronger depression.

[Eli]

soooo benzedrex does affect the dopamine?

[splooge gook]

why does feeling shitty necessarily have to do with how benzedrex effects your dopamine levels?

as far as i can tell it's a much more peripherally stimulating drug which usually means higher affinity for norepinephrine

[splooge gook]

cuz dopamine n shit man

[Eli]

why cant i just injext dopamine in my fuckin veins

[AlHarringtonCHN]

why does feeling shitty necessarily have to do with how benzedrex effects your dopamine levels?

as far as i can tell it's a much more peripherally stimulating drug which usually means higher affinity for norepinephrine

My bad, I mixed up inhaler ingrediants thinking benzedrex contained l-methamphetamine.
However...
Both l-meth and propylH bind with Dopamine*. Many people laugh at this but even extended use of Ephedra will cause mild to moderate discontinuation syndrome or "withdrawal" type symptoms due to sub-base Dopamine and NE levels and adjustment.

Sorry again

*wp
Propylhexedrine is a TAAR1 agonist like amphetamine.[11] Consequently, it reverses the transporters for dopamine, norepinephrine and serotonin, leading to a release of monoamines from presynaptic vesicles into the synaptic cleft.[11] The increased level of monoamines within the synapse results in increased activity at these receptors. Additionally, propylhexedrine appears to antagonize the VMAT2 transporter, leading to a further increase in the aforementioned monoamines.[11] The pharmacological actions of propylhexedrine are similar to that of structurally similar stimulant phenethylamines, such as amphetamine.[11]

[Max Headroom]

Dopamine up/downregulation wouldn't be much different from any other TAAR1 agonist or substituted amphetamine. The peripheral effects are the vasoconstriction, and possibly rhabdomyolysis, because I noticed when I do that fuckin cotton shit my muscles get dystonic, especially my vocal cords.