The Sanctuary
Carnality => Better Living Through Chemistry => Topic started by: Iudicium Infernalum on September 16, 2014, 05:17:30 pm
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Foreword.
The serotonin system plays through various means a major role in human cognitive and behavioral functions. In the world of recreational drug use the serotonin system is commonly considered to be mainly responsible for feelings of euphoria and well being. However the full scope of the serotonin or 5-HT system for short, and it’s functions are very complex indeed. Besides playing a part in normal human physiology. In this thread I will attempt to explain it’s psychopharmacological significance.
5-HT receptors
There are a couple of different types of serotonin receptors, namely; 5-HT1 through 7 which are mostly involved in increasing or decreasing cellular levels of cAMP (Cyclic adenosine monophosphate). It might be argued that activation of these recepetors contributes directly to the overall effects profile of the exogenous or endogenous substances, that can either agonise or antagonise these receptors. However to get a more complete picture of these mechanisms you must understand that every 5-HT receptor has it’s own set of subtypes with it’s own functions within the CNS.
5-HT Receptor subtypes
While the actual subtypes are quite numerous i will only go into specific detail about those that play a significant role in contributing to the effects of recreational and some medicinal drugs. Mostly to keep this thread psychopharmacology related and not a lesson in human physiology.
An overview of some 5-HT receptor subtypes and their functions.
5-HT1A
Cognitive funtion: Mood, sociability, appetite, sexual arousal, anxiety, aggresion, memory, sleep, analgesia and impulsivity.
Mode of operation: Agonising 5-HT1A receptors increases dopamine release, which is exhibited by an increase in mood, sociability and a decrease in aggresion and anxiety. Along with these effects 5-HT1A agonism also induces secretion of multiple hormones such as oxytocin, which most likely, also contribute to the effects i described above.
5-HT1A receptor agonism also results in decreased levels of glutamate and acetylcholine which has a negative effect on learning and memory formation.
Finally, some 5-HT1A receptors are co-localized with NK1 receptors. These NK1 receptors play an important part in the perception of pain. However when 5-HT1A receptors (That are co-localised with this other type of receptor.) are agonised, they inhibit the release of SP which is the endogenous ligand for NK1 receptors, thereby decreasing NK1 activation and promoting analgesia.
5-HT2A
Cognitive function: Perception, imagination, general cognition, mood, sleep, anxiety.
Mode of operation: These receptors are widely distributed through the CNS and are generally considered the most important when it comes to the mechanism of action of various psychedelics. The areas of the brain that are most densely populated by this type of receptor are the apical dendrites of the pyramidal cells of the cortex. Apical dendrites are the branched apex of the neurons of the pyramidal cells and pyramidal cells are the main type of excitatory neurons found within the brain. As such 5-HT2A receptors have the ability to significantly modulate cognitive processes. Via certain mechanisms 5-HT2A agonism results in increased glutaminergic activity and a decrease in the effectiveness of inhibition through GABAA receptors. Furthermore, a signaling cascade occurs through a series of complex interactions, which combined with the effects i described above, ultimately results in a decreased ability of the thalamus to proces sensory information and relay it properly to the cortex, where the faulty information is intergrated as psychedelic effects such as; colours, fractals, closed eye visuals, etcetera.
5-HT2C
Cognitive function: Mood, sexual arousal, sexual behavior, anxiety and sleep.
Mode of operation: 5-HT2C plays an important role in the release of dopamine in certain parts of the brain, however it primarily has an inhibitory funtion and to increase dopamine levels via 5-HT2C receptors we must use an antagonist. Psychedelics of the phenethylamine class are, besides partial agonists of 5-HT2A receptors, also antagonists of 5-HT2C receptors which influences the effects percieved by a someone while under the influence of this type of drug.
Antagonism of 5-HT2C receptors also results in increased levels of nor-epinephrine which may have a cardiovascular effect.
Agonism of 5-HT2C receptors also results in increased levels of certain hormones, primairly oxytocin and vasopressin.
Conclusion
With all this information in mind it is easy to see why the serotonin system plays an important part when it comes to psychoactive drugs. Mood, perception and general cognition are mostly governed by the serotonin system which consequentially contributes to the effects of drugs such as MDMA, LSD, 2c-B and various others.
Thank you for reading! Should you have any questions feel free to post them, also if you found any flaws in my explanation please feel free to point them out as well!
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This was very informational, thank you
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This was very informational, thank you
No problem, glad i could be of service :tup:
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Quality content. I'll read this on the shitter one day. :tup:
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Quality content. I'll read this on the shitter one day. :tup:
Not sure if compliment but thanks anyway :P
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Compliment. Toilet lectures are the best.
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Compliment. Toilet lectures are the best.
Thanks bro. :tup:
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this is literally paraphrased from wikipedia
except for the subunit(s) that gets u highZ
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this is literally paraphrased from wikipedia
except for the subunit(s) that gets u highZ
Yeah it's just that faggot psychomanthis, making posts and kissing ass again to try to get a foot in the door to be a 'moderator' or some other position of authority.
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this is literally paraphrased from wikipedia
except for the subunit(s) that gets u highZ
Nope. Only thing found on wikipedia is parts of the cognitive functions of receptor subtypes. Wiki has nothing on how the interaction between these receptors makes you experiene psychedelic effects. Nothing on the psychological effects of the experience of agonising versus antagonising and certainly nothing about noiciception, idiot. Also, let's see you make an intelligent post for once instead of your usual 'HURR DURR SYNCANS LOL'.
Contribute then you can criticize me or my work.
Yeah it's just that faggot psychomanthis, making posts and kissing ass again to try to get a foot in the door to be a 'moderator' or some other position of authority.
Let's see you post quality content then you can talk, dumbfuck.
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Let's see you post quality content then you can talk, dumbfuck.
I have, and not just a bunch of shit anyone can find on the internet if they want.
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Let's see you post quality content then you can talk, dumbfuck.
I have, and not just a bunch of shit anyone can find on the internet if they want.
Oh really? Let's see some of your threads then, come on i'm waiting.
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Oh really? Let's see some of your threads then, come on i'm waiting.
I will, but first, tell me, psychomanthis, did you type these articles you have been posting today? I mean, are you the one who wrote them, or did you cut and paste?
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Oh really? Let's see some of your threads then, come on i'm waiting.
I will, but first, tell me, psychomanthis, did you type these articles you have been posting today? I mean, are you the one who wrote them, or did you cut and paste?
I wrote them.
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I wrote them.
Uh huh. Sure. Anyway, the point I am trying to make is, I don't take shit off of the internet and present it as me 'gifting the community with knowledge'. Off the top of my head, since I have been here, I have posted instructions on how to make spore prints, several shoplifting posts, a few recipes, advice on harvesting wild mushrooms, and probably a bunch of other shit that I am not going to put forth the effort to find, because fuck you.
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other shit that I am not going to put forth the effort to find, because fuck you.
In other words you never contribute anything, gotcha'! Everything i post on here i have learned on and offline and because of my interest in drugs and pharmacology and having productive discussions about these things i post them here. So far i have neither seen you contribute any information of your own nor have you contributed productively to the discussion in this thread.
So if that's all you can bring to the table, what's the point in posting at all eh? Faggot.
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other shit that I am not going to put forth the effort to find, because fuck you.
In other words you never contribute anything, gotcha'! Everything i post on here i have learned on and offline and because of my interest in drugs and pharmacology and having productive discussions about these things i post them here. So far i have neither seen you contribute any information of your own nor have you contributed productively to the discussion in this thread.
So if that's all you can bring to the table, what's the point in posting at all eh? Faggot.
Heh everything I post is information of my own, and composed and written by me, off the top of my head. Every word. I don't even spellcheck. As usual you are wrong, and as usual, fuck you.
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this is literally paraphrased from wikipedia
except for the subunit(s) that gets u highZ
Nope. Only thing found on wikipedia is parts of the cognitive functions of receptor subtypes. Wiki has nothing on how the interaction between these receptors makes you experiene psychedelic effects. Nothing on the psychological effects of the experience of agonising versus antagonising and certainly nothing about noiciception, idiot. Also, let's see you make an intelligent post for once instead of your usual 'HURR DURR SYNCANS LOL'.
Contribute then you can criticize me or my work.
Yeah it's just that faggot psychomanthis, making posts and kissing ass again to try to get a foot in the door to be a 'moderator' or some other position of authority.
Let's see you post quality content then you can talk, dumbfuck.
(http://i.imgur.com/shnGv3w.png)
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I fucking hate you so much psychomanthis I want to have a stroke.
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other shit that I am not going to put forth the effort to find, because fuck you.
In other words you never contribute anything, gotcha'! Everything i post on here i have learned on and offline and because of my interest in drugs and pharmacology and having productive discussions about these things i post them here. So far i have neither seen you contribute any information of your own nor have you contributed productively to the discussion in this thread.
So if that's all you can bring to the table, what's the point in posting at all eh? Faggot.
Heh everything I post is information of my own, and composed and written by me, off the top of my head. Every word. I don't even spellcheck. As usual you are wrong, and as usual, fuck you.
Bitch how am i wrong? There's literally NOT A SINGLE thread here in BLTC that provides any information that you wrote. Just because you say i'm wrong doesn't make it so idiot. Go ahead keep talking, appearently that's all you can do. You're all talk you don't even have the threads to back your claims up LOL.
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not to mention there are like 7 ypes of serotonin receptors with various subtypes and you posted 3 subtypes in total
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this is literally paraphrased from wikipedia
except for the subunit(s) that gets u highZ
Nope. Only thing found on wikipedia is parts of the cognitive functions of receptor subtypes. Wiki has nothing on how the interaction between these receptors makes you experiene psychedelic effects. Nothing on the psychological effects of the experience of agonising versus antagonising and certainly nothing about noiciception, idiot. Also, let's see you make an intelligent post for once instead of your usual 'HURR DURR SYNCANS LOL'.
Contribute then you can criticize me or my work.
Yeah it's just that faggot psychomanthis, making posts and kissing ass again to try to get a foot in the door to be a 'moderator' or some other position of authority.
Let's see you post quality content then you can talk, dumbfuck.
(http://i.imgur.com/shnGv3w.png)
Right and what did i tell you???
Only thing found on wikipedia is parts of the cognitive functions of receptor subtypes.
You have zero reading comprehension sploo.
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not to mention there are like 7 ypes of serotonin receptors with various subtypes and you posted 3 subtypes in total
NO SHIT!? Just like i mentioned in the OP, i am only talking about those three to keep the thread psychopharmacology related, really sploo, did you even READ the op?
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not to mention there are like 7 ypes of serotonin receptors with various subtypes and you posted 3 subtypes in total
NO SHIT!? Just like i mentioned in the OP, i am only talking about those three to keep the thread psychopharmacology related, really sploo, did you even READ the op?
you think only three of the serotonin subreceptors are in any way related to the brain and of significance?
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not to mention there are like 7 ypes of serotonin receptors with various subtypes and you posted 3 subtypes in total
NO SHIT!? Just like i mentioned in the OP, i am only talking about those three to keep the thread psychopharmacology related, really sploo, did you even READ the op?
you think only three of the serotonin subreceptors are in any way related to the brain and of significance?
Sploo, don't even try to start a pharmacology discussion with me nigger, you know you'll lose.
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Bitch how am i wrong? There's literally NOT A SINGLE thread here in BLTC that provides any information that you wrote. Just because you say i'm wrong doesn't make it so idiot. Go ahead keep talking, appearently that's all you can do. You're all talk you don't even have the threads to back your claims up LOL.
Just because I 'dont have any threads in bltc' doesn't mean I don't contribute content. That is why you are wrong. And I 'don't even have the threads' because my content is mostly posts in others threads, if you want to talk shit about my content, it must be important to you, so you fucking go look it up yourself, I don't give a fuck.
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hurr durr how are calcium channels significant?
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and also how it relates to alterations by a certain kind of hallucinogen group
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hurr durr how are calcium channels significant?
Hurr durr in the same way potassium channels are significant, action potential faggot.
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hurr durr how are calcium channels significant?
Hurr durr in the same way potassium channels are significant, action potential faggot.
how are they significant to dissociatives? specify how glutamate allows this whole process to go about, lock n key
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hurr durr how are calcium channels significant?
Hurr durr in the same way potassium channels are significant, action potential faggot.
how are they significant to dissociatives? specify how glutamate allows this whole process to go about, lock n key
Why don't you just talk about what the OP is about. We can have this discussion if you will, just post another thread.
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What use is this OP as 'content' anyways? Who here is ever going to even read the op? At least the stuff I post is relevent in real life situations like making money on the streets and etc.
And I am glad this thread is trashed, I mean, look at this fucking guy acting like some big drug expert in one post and then in another talking about 10mgs of fentanyl, not to mention some of the previously mentioned health problems exposed in past threads. If you are so fucking smart why did you have the worst habit out of anyone I have ever heard of in my life? You'd think you would know better.
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Reported for derailing.
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Reported for derailing.
Oh my god you reported me! Oh my whatever am I going to do? You fucking sickening kiss ass.
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Guys, could you at least take of your shirts and oil your bodies up?
Sheesh.
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OP, as far as I can tell you derailed your thread as much as anyone else, contributed to the flame war, and posted off topic. If you had chosen to respond in a different way, or not respond at all, aka don't feed the trolls, it may have turned out differently.
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OP, as far as I can tell you derailed your thread as much as anyone else, contributed to the flame war, and posted off topic. If you had chosen to respond in a different way, or not respond at all, aka don't feed the trolls, it may have turned out differently.
http://i2.kym-cdn.com/photos/images/newsfeed/000/276/747/bf9.gif (http://i2.kym-cdn.com/photos/images/newsfeed/000/276/747/bf9.gif)
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OP, as far as I can tell you derailed your thread as much as anyone else, contributed to the flame war, and posted off topic. If you had chosen to respond in a different way, or not respond at all, aka don't feed the trolls, it may have turned out differently.
THIS
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OP, as far as I can tell you derailed your thread as much as anyone else, contributed to the flame war, and posted off topic. If you had chosen to respond in a different way, or not respond at all, aka don't feed the trolls, it may have turned out differently.
Oh so when you get someone to respond derailing a thread is ok? Good to know i think i'll go illicit some responses from people in their threads so i can derail them without getting into trouble. It's like you're walking on the street and someone shoots you, when you shoot back the cop says: Well son, you shot back so i think i'll let the perpetrator go. Sounds logical :facepalm:
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Oh so when you get someone to respond derailing a thread is ok? Good to know i think i'll go illicit some responses from people in their threads so i can derail them without getting into trouble. It's like you're walking on the street and someone shoots you, when you shoot back the cop says: Well son, you shot back so i think i'll let the perpetrator go. Sounds logical :facepalm:
Me responding to another poster in the thread is not 'derailing', you weeping tattletale faggot. I posted to splew in response to his post, that you are a fucking kiss ass and that your OP sucked. You then engaged me in an argument, saying I don't contribute content and that I am a 'dumb fuck'. I didn't derail shit, motherfucker. Enjoy your gay brain chemical thread, you sycophantic lackey.
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serotonin gets u hai, serotonin receptors have sybtypes, here's a list of what 3 of the subtypes do.this is why yhtey get you hai.